| Title |
Fig. 1. Effect of CaCCinh-A01 on the probability of the open state of single ANO6 channels of HEK293 cells. Experiments performed in an inside-out configuration at a potential of +40 mV were used for analysis. a - Fragment of current recording through CaCC ANO6 channels after addition of 10 μM [Ca2+]i and subsequent application of 20 μM CaCCinh-A01. Extended current recording fragments and amplitude histograms are indicated below the current recording fragment. b - Volt-ampere characterization of CaCC ANO6 channels after addition of 20 μM CaCCinh-A01 to the intracellular side of the membrane. c - Open-state probability of CaCC ANO6 channels activated by addition of 10 μM [Ca2+]i at 30 s intervals immediately before (1, black squares) and after application of CaCCinh-A01 (2, gray squares) (p < 0.05). |