Russian Clinical Laboratory DiagnosticsRussian Clinical Laboratory DiagnosticsКлиническая лабораторная диагностика0869-20842412-1320Eco-Vector65396810.17816/cld653968ReviewsОбзорыReview ArticleHigh-tech biotechnologies in clinical laboratory diagnosticsНаукоёмкие биотехнологии в клинической лабораторной диагностикеhttps://orcid.org/0009-0004-1761-1518YarovayaGalina A.ЯроваяГалина Алексеевна
Russian Federation

Dr. Sci. (Biology), Professor

д-р биол. наук, профессор

galina.yarovaya.31@gmail.comhttps://orcid.org/0000-0001-8665-91294547-5317MetelskayaVictoria A.МетельскаяВиктория Алексеевна
Russian Federation

Dr. Sci. (Biology), Professor

д-р биол. наук, профессор

vmetelskaya@gnicpm.ruRussian Medical Academy of Continuous Professional EducationРоссийская медицинская академия непрерывного профессионального образованияNational Medical Research Center for Therapy and Preventive MedicineНациональный медицинский исследовательский центр терапии и профилактической медицины2802202569102662750502202507022025Copyright ©; 2025, Yarovaya G.A., Metelskaya V.A.Copyright ©; 2025, Яровая Г.А., Метельская В.А.2025Yarovaya G.A., Metelskaya V.A.Яровая Г.А., Метельская В.А.https://creativecommons.org/licenses/by-nc-nd/4.0https://kld-journal.fedlab.ru/0869-2084/article/view/653968

This review presents an analysis of the current literature on the achievements in the development of the latest high-tech biomedical technologies and the prospects for their implementation in the practice of clinical diagnostic laboratories. The publications were searched in the MEDLINE, PubMed, Scopus, Cochrane Library and Google Scholar databases. The advent of high-tech research methods has revolutionized biomedical research. Many of the most promising technologies of personalized medicine are combined within the framework of omix technologies: genomics, transcriptomics, proteomics, metabolomics, lipidomics, etc. The main methods used in clinical diagnostic laboratories for the diagnosis of circulating biomarkers of various diseases are considered. The introduction of high-tech technologies in the activities of clinical diagnostic laboratories will change the approach to medical diagnostics, making it more accurate, faster and personalized. These technologies represent a synthesis of scientific discoveries, engineering solutions and high standards of analytical chemistry. They open up new opportunities for doctors and researchers, offering innovative approaches to the study of biological processes, which leads to an understanding of the molecular and cellular foundations of pathology.

В настоящем обзоре представлен анализ современной литературы, посвящённой достижениям в разработке новейших наукоёмких биомедицинских технологий и перспективам их внедрения в практику работы клинико-диагностических лабораторий. Поиск публикаций проводился в базах данных MEDLINE, PubMed, Scopus, Cochrane Library и Google Scholar. Появление высокотехнологичных методов исследования произвело революцию в медико-биологических исследованиях. Многие наиболее перспективные технологии персонализированной медицины объединяются в рамках омиксных технологий: геномики, транскриптомики, протеомики, метаболомики, липидомики и др. Рассмотрены основные методы, которые используются в клинико-диагностических лабораториях для диагностики циркулирующих биомаркеров различных заболеваний. Внедрение наукоёмких технологий в деятельность клинико-диагностических лабораторий изменит подход к медицинской диагностике, сделает её более точной, быстрой и персонализированной. Эти технологии представляют собой синтез научных открытий, инженерных решений и высоких стандартов аналитической химии. Они открывают новые возможности для врачей и исследователей, предлагая инновационные подходы к изучению биологических процессов, что ведёт к пониманию молекулярных и клеточных основ патологии.

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