Screening for iron deficiency conditions as an effective tool for donor blood management

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Regular blood donation may lead to the depletion of iron stores in donors, which affects their health and impacts the quality of collected blood components. This review highlights the relevance of monitoring iron metabolism in donor practice and its role in blood donor management systems.

A scientific data search was conducted from February to October 2024 using the following electronic databases: PubMed, Scopus, Web of Science, eLIBRARY.RU, and Google Scholar. The analysis included original research articles, systematic reviews, meta-analyses, and clinical guidelines.

Modern approaches to donor potential management should include screening of iron metabolism indicators, personalized donation interval planning, and timely prevention of iron deficiency conditions. The implementation of iron status monitoring programs ensures donor safety, optimizes donation frequency, and helps maintain stable supplies of blood components of appropriate quality.

The authors place particular emphasis on the cost-effectiveness of preventive measures compared to the treatment of developed iron deficiency, which is crucial for the rational use of blood service resources.

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作者简介

Karina Chirkova

N.V. Sklifosovsky Research Institute for Emergency Medicine

编辑信件的主要联系方式.
Email: Korish112@mail.ru
ORCID iD: 0000-0003-2583-9956
俄罗斯联邦, Moscow

Alexander Kostin

N.V. Sklifosovsky Research Institute for Emergency Medicine

Email: KostinAI@sklif.mos.ru
ORCID iD: 0000-0001-7542-851X
SPIN 代码: 7119-8871

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow

Svetlana Lugovskaya

Russian Medical Academy of Continuous Professional Education

Email: slugovskaya@mail.ru
ORCID iD: 0000-0002-6405-3422
SPIN 代码: 2249-6272

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow

Natalia Sochilova

The industry center for the development and implementation of information systems

Email: sochilova.nataliya@yandex.ru
ORCID iD: 0009-0007-8925-8727
俄罗斯联邦, Moscow

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2. Fig. 1. The scheme of iron intake and distribution in the body (created using the Biorender Internet resource).

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3. Fig. 2. The iron exchange scheme (created using the Biorender Internet resource and [10]). In the duodenum, Fe3+ is converted to Fe2+ by vitamin C-dependent ferrireductase (duodenal cytochrome B) of the brush border of the erythrocyte. Free iron (Fe2+) is transported through the brush border of the apical membrane of enterocytes using a divalent metal transporter DMT-1.

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版权所有 © Chirkova K.S., Kostin A.I., Lugovskaya S.A., Sochilova N.A., 2024

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