Исследования механизмов развития и электростимуляционных подходов терапии мигрени

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Аннотация

Мигрень с ее высокой распространенностью, сложным патогенезом, включающим изменения со стороны нервной, иммунной, сердечно-сосудистой систем, и с ограниченной эффективностью медикаментозного лечения представляет собой одну из актуальных проблем современной медицины. Требуется поиск новых фармакологических мишеней и разработка фармакологических препаратов. С конца XX в. исследования показали возможное участие дофаминергической системы мозга в патогенезе мигрени. Мигренозные боли часто сочетаются с предварительной зевотой и сонливостью, сопровождаются тошнотой и рвотой, постдромальной сонливостью, эйфорией и полиурией, что может быть связано с дофаминергической активностью. Изучение дофаминергических механизмов развития мигрени может лечь в основу создания новых линеек лекарств для терапии цефалгий. Одной из проблем в современной клинической практике является подбор терапии для лечения и профилактики мигрени. Чрезмерное неконтролируемое использование обезболивающих препаратов при болевых приступах увеличивает риск перехода эпизодической мигрени в хроническую форму. В связи с этим в последнее время большое внимание уделяется изучению немедикаментозных методов лечения, среди которых особое место занимает нейромодуляция. Электрическая стимуляция шейного отдела спинного мозга показала высокую эффективность при хронической мигрени в клинике, однако механизмы клинических эффектов не определены. В настоящем обзоре описаны современные представления о роли дофамина в развитии мигрени, рассмотрена новая экспериментальная модель для изучения механизмов ее развития – животные с дофаминергической дисрегуляцией, с нокаутом переносчика дофамина (DAT-KO), описаны возможные механизмы, предпосылки и опыт использования спинальной электростимуляции для лечения мигрени.

Об авторах

А. А. Кочнева

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”

Федеральная территория Сириус, Россия

Е. В. Герасимова

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”

Федеральная территория Сириус, Россия

Д. Р. Еникеев

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”; Институт физиологии им. И.П. Павлова РАН

Федеральная территория Сириус, Россия; Санкт-Петербург, Россия

С. П. Коновалова

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”

Федеральная территория Сириус, Россия

Ю. И. Сысоев

Институт физиологии им. И.П. Павлова РАН; Институт трансляционной биомедицины, Санкт-Петербургский государственный университет

Санкт-Петербург, Россия; Санкт-Петербург, Россия

А. В. Калуев

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”; Институт трансляционной биомедицины, Санкт-Петербургский государственный университет

Федеральная территория Сириус, Россия; Санкт-Петербург, Россия

П. Е. Мусиенко

Научный центр генетики и наук о жизни, направление “Нейробиология”, научно-технологический университет “Сириус”; Life Improvement by Future Technologies Center “LIFT”; Центр мозга и нейротехнологий

Email: musienko.pe@talantiuspeh.ru
Федеральная территория Сириус, Россия; Москва, Россия; Москва, Россия

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