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The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review

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1. Title Title of document The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review
2. Creator Author's name, affiliation, country Devesh Kapoor; Department of Pharmaceutical Technology, Dr. Dayaram Patel Pharmacy College
2. Creator Author's name, affiliation, country Shirisha Chilkapalli; Department of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University
2. Creator Author's name, affiliation, country Bhupendra Prajapati; Department of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University
2. Creator Author's name, affiliation, country Paul Rodriques; Department of Pharmaceutical Technology, Krishna School of Emerging Technology and Applied Research
2. Creator Author's name, affiliation, country Ravish Patel; Department of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology
2. Creator Author's name, affiliation, country Sudarshan Singh; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University
2. Creator Author's name, affiliation, country Sankha Bhattacharya; Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM’S NMIMS School of Pharmacy and Technology Management
3. Subject Discipline(s)
3. Subject Keyword(s) Lipid nanoparticles; biologicals; nucleic acids; protein-based products; vaccines; DNA/RNA therapies.
4. Description Abstract

:Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale production. Despite recent research efforts, challenges in stability, toxicity, and regulatory concerns have limited the commercial availability of LNP-based products. This review explores the applications, administration routes, challenges, and future directions of LNPs in delivering biopharmaceuticals.

5. Publisher Organizing agency, location Bentham Science
6. Contributor Sponsor(s)
7. Date (DD-MM-YYYY) 01.01.2024
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://kld-journal.fedlab.ru/1389-2010/article/view/644606
10. Identifier Digital Object Identifier (DOI) 10.2174/0113892010268824231122041237
11. Source Title; vol., no. (year) Current Pharmaceutical Biotechnology; Vol 25, No 15 (2024)
12. Language English=en
13. Relation Supp. Files
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2024 Bentham Science Publishers