Radio-mitigation properties of α-lipoic acid when used alone and in combination with metformin or ethylmethylhydroxypyridine succinate (mexidol) in mice after exposure to X-ray radiation

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Abstract

This study explored the radio-mitigation properties of α-lipoic acid and combination of α-lipoic acid with metformin and mexidol in animals during the process of X-ray irradiation. The results of the micronucleus test for measuring radiation-induced DNA damage of polychromatophilic red blood cells in the bone marrow of mice showed that α-lipoic acid has gene-protective and radio-mitigation properties in vivo. A study on the survival rate of the lethal dose-irradiated mice within 30 days confirmed that α-lipoic acid has radio-mitigation properties. The radio-mitigation effect of α-lipoic acid is dose-dependent, the effect increases with decreasing dose. α-lipoic acid in combination with mexidol and metformin exhibited a weaker radio-mitigation effect.

About the authors

E. E Karmanova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences;Institute of Cell Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

A. V Chernikov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

A. M Usacheva

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

V. I Bruskov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Author for correspondence.
Email: silisti@bk.ru
Pushchino, Moscow Region, Russia

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