Numerical Simulation of the Diffusion of Electroactive Molecule in Biosimilar Hydrogel Media

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Abstract

Based on experimental data of cyclic voltammetry, the values of the diffusion coefficients for toluidine blue in alginate hydrogel, gelatine hydrogel and alginate-gelatine hydrogels were obtained. Using the experimental values of the coefficients in a numerical model, the values of the recovery of flows have been calculated showing them consistent with what was the experimental. It is proposed to use the period in time during which the value of the flow force reaches the value of steady state flow force as an indicator of the diffusion properties of the hydrogel medium. The findings of this study can be used for the development of methods for the evaluation of the diffusion properties of hydrogel media: bioinks and tissue-engineered structures.

About the authors

I. A Cherenkov

Udmurt State University

Email: ivch75@yandex.ru
Izhevsk, 426034 Russia

M. D Krivilev

Udmurt State University; Udmurt Federal Research Center, Ural Branch of the Russian Academy of Sciences

Izhevsk, 426034 Russia; Izhevsk, 426067 Russia

M. M Ignat'eva

Udmurt State University

Izhevsk, 426034 Russia

A. Yu Emel'yanova

Udmurt State University

Izhevsk, 426034 Russia

V. G Sergeev

Udmurt State University

Izhevsk, 426034 Russia

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