Properties of Resorbable Conduits Based on Poly(L-lactide) Nanofibers and Chitosan Fibers for Peripheral Nerve Regeneration

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Abstract

Tubular conduits have been developed to regenerate peripheral nerves and repair defects with a diastase more than 3 cm. An optimal design of a conduit consists of a tube based on poly(L-lactide) nanofibers and chitosan composite fibers with chitin nanofibrils. In the study performed with in vivo model for motor dysfunction, nerve functional status has been assessed by means of the sciatic functional index. It has been shown that chitosan monofibers and chitosan composite fibers with chitin nanofibrils in the design of conduits can increase the regeneration rate of the sciatic nerve, the sciatic functional index is 76−83. The degree of nerve conduction recovery, determined by measuring the amplitude of the M response, is 46%. The developed conduit design imitates the oriented architecture of the nerve, facilitates electrical communication between the ends of the damaged nerve, and promotes increased rate of nerve regeneration and the direction of nerve growth.

About the authors

N. A Tagandurdyyeva

Peter the Great St. Petersburg Polytechnic University

Email: jemala1996@gmail.com
Saint Petersburg, 195251 Russia

M. A Trube

Peoples' Friendship University of Russia

Moscow, 117198 Russia

I. O Shemyakin

Pavlov First State Medical University of St. Petersburg

Saint Petersburg, 197022 Russia

D. N Solomitskiy

Pavlov First State Medical University of St. Petersburg

Saint Petersburg, 197022 Russia

G. V Medvedev

Pavlov First State Medical University of St. Petersburg

Saint Petersburg, 197022 Russia

E. M Ivan’kova

Peter the Great St. Petersburg Polytechnic University

Saint Petersburg, 195251 Russia

I. P Dobrovolskaya

Peter the Great St. Petersburg Polytechnic University; Institute of Macromolecular Compounds, Russian Academy of Sciences

Saint Petersburg, 195251 Russia; Saint Petersburg, 199004 Russia

V. Ye Yudin

Peter the Great St. Petersburg Polytechnic University; Institute of Macromolecular Compounds, Russian Academy of Sciences

Saint Petersburg, 195251 Russia; Saint Petersburg, 199004 Russia

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