Sinthesis and biological properties of N-acylaminoacryloylhistamines and the corresponding 4-arylideneimidazol-5(4H)-ones

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Abstract

The reaction of unsaturated 4-arylidenoxazol-5(4 H )-ones with 2-(1 H -imidazol-4-yl)ethan-1-amine dihydrochloride was used to synthesize and describe the physicochemical characteristics of histamine N -acyl derivatives containing α,β-dehydroamino acids residues, as well as the corresponding 4-arylidenimidazol-5(4 H )-ones. Anticholinesterase and antiradical properties of the synthesized compounds were studied. It was revealed that the studied substances have anticholinesterase activity both acetylcholinesterase and butyrylcholinesterase and have almost no antiradical activity.

About the authors

V. O Topuzyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. A Hovhannisyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

S. R Tosunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: syuzitos@mail.ru

T. T Makichyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia;Russian-Armenian University

N. A Hovhannisyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. A Shahkhatuni

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

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