Kinetics of the reaction of phosphoenol pyruvic acid with tetranitrosyl iron complex with penicylamine ligands – nitrogen monoxide donor

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The kinetic patterns of the reaction of phosphoenolpyruvic acid (PEP) with the NO donor – nitrosyl iron complex with penicillamine ligands (PEN) were studied using mass spectrometric analysis. It has been established that the PEP molecule in an aqueous solution interacts with PEN. The kinetic curves demonstrate the complex multi-stage nature of the reaction. A kinetic model of the process is proposed that quantitatively describes the experimental data.

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B. Psikha

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

Email: easar@icp.ac.ru
俄罗斯联邦, Chernogolovka

E. Saratovskikh

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: easar@icp.ac.ru
俄罗斯联邦, Chernogolovka

N. Sanina

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences; Lomonosov Moscow State University , Faculty of Fundamental Physical and Chemical Engineering; Moscow State Regional University

Email: easar@icp.ac.ru

Moscow State Regional University, Scientific and Educational Center “Medical Chemistry”

俄罗斯联邦, Chernogolovka; Moscow; Mytishchi

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2. Fig. 1. Structural formula of phosphoenolpyruvic acid (PEP).

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3. Fig. 2. Structural formula of tris(hydroxymethyl)-aminomethane hydrochloride (Tris-HCl).

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4. Fig. 3. Structure of the dication of the tetranitrosyl iron complex with penicillamine ligands – NO donor (PEN).

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5. Fig. 4. Mass spectrum of a solution of FEP in water. Ionization type – ESI, eluent – ​​acetonitrile-water; spectra were assigned based on the distribution of negatively charged ions.

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6. Fig. 5. Change in intensity over time of the MS peak of FEP (m/z = 167 [M–H]) during the reaction with the PEN complex. The initial concentration ratio of FEN: PEN in M: 1 – 1 : 1; 2 – 1 : 2; 3 – 1 : 3.

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7. Fig. 6. Kinetic curves of FEP consumption during interaction with PEN. Initial concentrations of B, mol l–1: 1 – [FEP] = 9.5 10–4, [C] = 9.7 10–4; 2 – [FEP] = 9.3 10–4, [C] = 20.4 10–4; 3 – [FEP] = 8.8 10–4, [C] = 30.2 10–4. Dots are experimental values, solid lines are calculated curves.

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