Direct synthesis of a new hybrid molecules based on isomerically pure 5Z,9Z-dienoic acids and monocarbonyl derivatives of curcuminoids

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Abstract

Synthesis of previously undescribed hybrid compounds based on monocarbonyl derivatives of curcumin and 5 Z ,9 Z -dienoic acids with yields of 61-67% was carried out for the first time. Unsaturated acids are synthesized using at the key stage of stereoselective reaction of intermolecular cross-cyclomagnesiation of aliphatic and O-containing 1,2-dienes catalyzed by Cp2TiCl2.

About the authors

I. I Islamov

Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences

Email: iislamovi@gmail.com

A. V Yusupova

Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences

Email: iislamovi@gmail.com

V. A Dyakonov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: iislamovi@gmail.com

U. M Dzhemilev

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: iislamovi@gmail.com

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