Properties of immune exosomes and methods of their determination

Мұқаба


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Exosomes are extracellular nanoscale vesicles of endocytic origin that are actively secreted by cells of all pro- and eukaryotes. Human exosomes have a phospholipid bilayer that protects their contents from enzymatic degradation — proteins, cytokines, lipids, mRNAs, microRNAs, etc. There are many known variants of the contents of exosomes that carry basic intercellular information and are involved in all physiological processes. The search for literary sources was carried out with the help of the National Medical Library (NLM), namely the PubMed database. This review consists of 45 scientific articles. Their pathogenic role in cancer, cardiovascular diseases, asthma, infections and other diseases has been proven. The characteristics of exosomes, including their physical properties and markers, underlie various methods of their isolation, which makes it possible to study interactions between specific exosomes and target cells. The study of exosomes has formed the basis for fundamentally new approaches to understanding pathogenesis, developing highly informative diagnostic methods, targeted drug delivery, and creating new-generation vaccines. Attention is also drawn to the possibility of using exosomes for the treatment of human diseases derived from milk, animal, human, plant and parasite cell cultures, as well as the manufacture of artificial exosomes for targeted drug delivery and the creation of new generation vaccines.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Victoria Garib

International Center for Molecular Allergology

Хат алмасуға жауапты Автор.
Email: vgarib@inbox.ru
ORCID iD: 0000-0003-3855-217X

MD, Dr. Sci. (Medicine), Professor

Өзбекстан, Tashkent

Firuz Garib

Russian Medical Academy of Continuous Professional Education

Email: fgarib@yandex.ru
ORCID iD: 0000-0003-3749-1950

MD, Dr. Sci. (Medicine), Professor

Ресей, Moscow

Anna Rizopulu

Russian Medical Academy of Continuous Professional Education; Russian Academy of Sciences

Email: annarizopulu@inbox.ru
ORCID iD: 0009-0008-8631-0339
SPIN-код: 6286-6542

MD, Dr. Sci. (Biology)

Ресей, Moscow; Moscow

Әдебиет тізімі

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© Garib V.F., Garib F.Y., Rizopulu A.P., 2024

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