The role of genetic variants of genes for suspension to venous thrombosis in children born to mothers with recurrent miscarriage

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BACKGROUND: Venous thrombosis is associated with hereditary and acquired conditions characterized by increased activation of the coagulation activity of the hemostatic system in blood vessels. Idiopathic venous thrombosis can often occur in childhood and can also be associated with certain genetic variants of hereditary predisposition.

AIM: To analyze the association of 8 genetic variants (F2 20210 G>A, F5 1691 G>A, F7 10976 G>A, F13 G>T, FGB G455A, ITGA2 807 C>T, ITGB3 1565 T>C, PAI-1-675 5G>4G) with venous thrombosis in children born to mothers with a history of recurrent miscarriage.

MATERIALS AND METHODS: The patient group included 322 children aged 6 to 15 years (average age 8.5 years), who had a history of episodes of venous thrombosis of various locations, born to mothers with a history of recurrent miscarriage. The comparison group included 159 healthy children also aged from 6 to 15 years (average age 8.5 years), who had no history of episodes of venous thrombosis and who were also born to mothers with recurrent miscarriage. Molecular genetic analysis was carried out using real-time polymerase chain reaction with automatic analysis of melting curves.

RESULTS: Based on the results of an analysis of the association of genetic variants with venous thrombosis in children born to mothers with burdened obstetric and gynecological history, a connection with this pathology was established for genetic variants F5 1691 G>A (genotype GA+AA; odds ratio 3.70, 95% confidence interval 1.33–10.33, p <0.0072) and ITGB3 1565 T>C (CC genotype; odds ratio 2.26, 95% confidence interval 1.02–5.00, p <0.0370).

CONCLUSION: Thus, we established an association of 2 genetic variants (Leiden mutation and ITGB3 1565 T>C) with venous thrombosis in children born to mothers with recurrent miscarriage. Based on our study, we can recommend molecular genetic testing of these variants as markers of hereditary predisposition to thrombosis.

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Sobre autores

Oleg Perevesentsev

Rostov State Medical University; Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky

Email: PZPO@mail.ru
ORCID ID: 0000-0002-7070-3209
Código SPIN: 8400-2602

MD, Cand. Sci. (Medicine)

Rússia, 29 Nakhichevansky lane, 344022 Rostov-on-Don; 38, Aviatorov st., 119620 Moscow

Ilgar Mamedov

Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky

Email: is_mamedov@mail.ru
ORCID ID: 0000-0003-0783-2873
Código SPIN: 7171-2625

MD, Cand. Sci. (Medicine)

Rússia, 38, Aviatorov st., 119620 Moscow

Alexey Krapivkin

Scientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky

Autor responsável pela correspondência
Email: krapivkin@list.ru
ORCID ID: 0000-0002-4653-9867
Código SPIN: 2876-8470

MD, Dr. Sci. (Medicine), Assistant Professor

Rússia, 38, Aviatorov st., 119620 Moscow

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