Influence of general cooling on the formation of adaptive reactions depending on the background level of lymphocytes with markers of early activation

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Abstract

A study was carried out of the peculiarities of the formation of adaptive reactions in response to short-term general cooling in practically healthy individuals, depending on the background level of lymphocytes with markers of early activation. It has been shown that an increased background level of activated lymphocytes with receptors for IL-2 and transferrin is associated with activation of the hypothalamic-pituitary-adrenal axis, while a lower level is associated with the sympathetic-adrenal-medullary axis. Regardless of the level of lymphocyte activation, the examined patients recorded similar hemodynamic reactions associated with the preservation of thermal homeostasis and activation of thermogenesis mechanisms. A low content of lymphocytes with early activation markers increases the risk of chronic infectious processes in people living in the North due to a higher background level of general inflammation (C-reactive protein, extracellular ATP and LCR), without increasing the phagocytic and secretory activity of neutrophils, as well as increase in tissue hypoxia after cold exposure.

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About the authors

V. P. Patrakeeva

N. Laverov Federal Center

Author for correspondence.
Email: patrakeewa.veronika@yandex.ru

Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences

Russian Federation, Nikolsky Ave., 20, Archangelsk, 163020

E. V. Kontievskaya

N. Laverov Federal Center

Email: patrakeewa.veronika@yandex.ru

Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences

Russian Federation, Nikolsky Ave., 20, Archangelsk, 163020

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Supplementary files

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2. Fig. 1. Example of a cytofluorogram when assessing the level of lymphocytes with CD25+ and CD71+ markers (first cluster)

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3. Fig. 2. An example of a cytofluorogram when assessing the level of lymphocytes with CD25+ and CD71+ markers (second cluster)

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4. Fig. 3. Concentration of catecholamines and cortisol in groups depending on the level of activated cells, * – p < 0.05, *** – p < 0.01

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5. Fig. 4. The content of lymphocytes with signs of apoptosis and necrotic cells in groups depending on the level of activated cells, ** – p < 0.01

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6. Fig. 5. Content of ferritin, lactoferrin and transferrin in groups depending on the level of activated cells, ** – p < 0.01

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7. Fig. 6. Change in arterial pressure in groups depending on the level of activated cells, ** – p < 0.01

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8. Fig. 7. Leukocyte levels in peripheral blood before and after general cooling, ** – p < 0.01, reliability of differences within groups

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9. Fig. 8. Concentrations of iron-containing proteins before and after general cooling, ** – p < 0.01, significance of differences within groups.

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