Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses


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Abstract

Background:Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion.

Aim:This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI.

Methods:Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-like Receptor 4 (TLR4). This finding indicates eplerenone's potential as a potent preventive agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis of IRI.

Results:This finding positions eplerenone as a promising candidate for further clinical investigation and consideration for future clinical practice.

Conclusion:The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.

About the authors

Myltykbay Rysmakhanov

Department of Surgery and Urology No. 2,, West Kazakhstan Marat Ospanov State Medical University

Author for correspondence.
Email: info@benthamscience.net

Afshin Zare

, PerciaVista R&D Co.

Email: info@benthamscience.net

Aibolat Smagulov

Department of Surgery and Urology No. 2,, West Kazakhstan Marat Ospanov State Medical University

Email: info@benthamscience.net

Nurgul Abenova

Department of General Medical Practice No. 1, West Kazakhstan Medical University

Email: info@benthamscience.net

Nadiar Mussin

Department of Surgery and Urology No. 2, West Kazakhstan Medical University

Email: info@benthamscience.net

Yerlan Sultangereyev

Department of Surgery and Urology No. 2, West Kazakhstan Medical University

Email: info@benthamscience.net

Bazylbek Zhakiyev

Department of Surgery and Urology No. 2, West Kazakhstan Medical University

Email: info@benthamscience.net

Gani Kuttymuratov

Department of Surgery and Transplantation,, Aktobe Medical Center

Email: info@benthamscience.net

Mehmet Haberal

Department of General Surgery, Division of Transplantation,, Başkent University

Email: info@benthamscience.net

Nazanin Jafari

, PerciaVista R&D Co.

Email: info@benthamscience.net

Hanieh Baneshi

, PerciaVista R&D Co.

Email: info@benthamscience.net

Shabnam Bakhshalizadeh

Reproductive Development, Murdoch Children's Research Institute

Email: info@benthamscience.net

Mahdi Mahdipour

Stem Cell Research Center, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Farhad Rahmanifar

Department of Basic Sciences, School of Veterinary Medicine,, Shiraz University

Email: info@benthamscience.net

Amin Tamadon

Department of Surgery and Transplantation, Aktobe Medical Center

Email: info@benthamscience.net

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