Construction, Features and Regulatory Aspects of Organ-chip for Drug Delivery Applications: Advances and Prospective


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:Organ-on-chip is an innovative technique that emerged from tissue engineering and microfluidic technologies. Organ-on-chip devices (OoCs) are anticipated to provide efficient explanations for dealing with challenges in pharmaceutical advancement and individualized illness therapies. Organ-on-chip is an advanced method that can replicate human organs' physiological conditions and functions on a small chip. It possesses the capacity to greatly transform the drug development process by enabling the simulation of diseases and the testing of drugs. Effective integration of this advanced technical platform with common pharmaceutical and medical contexts is still a challenge. Microfluidic technology, a micro-level technique, has become a potent tool for biomedical engineering research. As a result, it has revolutionized disciplines, including physiological material interpreting, compound detection, cell-based assay, tissue engineering, biological diagnostics, and pharmaceutical identification. This article aims to offer an overview of newly developed organ-on-a-chip systems. It includes single-organ platforms, emphasizing the most researched organs, including the heart, liver, blood arteries, and lungs. Subsequently, it provides a concise overview of tumor-on-a-chip systems and emphasizes their use in evaluating anti-cancer medications.

Sobre autores

Babita Gupta

Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University

Email: info@benthamscience.net

Rishabha Malviya

Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University

Autor responsável pela correspondência
Email: info@benthamscience.net

Saurabh Srivastava

School of Pharmacy, KPJ Healthcare University College (KPJUC)

Autor responsável pela correspondência
Email: info@benthamscience.net

Irfan Ahmad

Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University

Email: info@benthamscience.net

Safia Rab

Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University

Email: info@benthamscience.net

Prerna Uniyal

School of Pharmacy, Graphic Era Hill University

Email: info@benthamscience.net

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