The Effects of Sumac Consumption on Inflammatory and Oxidative Stress Factors: A Systematic Review of Randomized Clinical Trials


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Background:Rhus coriaria L., commonly known as Sumac, is a plant from the Anacardiaceae family that is known for its high phytochemical content. These phytochemicals have the potential to effectively manage inflammation and oxidative stress. To explore the existing evidence on the impact of Sumac consumption on inflammation and oxidative stress, we conducted a systematic review of randomized controlled trials.

Methods:We conducted a comprehensive search of Medline/PubMed, Scopus, and Web of Science from inception to August 2023 to identify relevant studies examining the effects of Sumac on biomarkers of inflammation and oxidative stress. The selected studies were assessed for risk of bias using the Cochrane tool.

Results:A total of seven trials were included in this review. Among these trials, three focused on diabetes patients, while the remaining four involved individuals with fatty liver, overweight individuals with depression, and those with polycystic ovary or metabolic syndrome. Five studies reported the effects of Sumac on oxidative stress, with four of them demonstrating a significant reduction in malondialdehyde (MDA) levels and an increase in total antioxidant capacity (TAC) and paraoxonase 1 (PON1). Regarding inflammation, one study reported no significant difference in tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels between the intervention and control groups. The results for high-sensitivity C-reactive protein levels, reported in five trials, were inconsistent.

Conclusion:Sumac consumption over time may positively affect oxidative stress, although short-term use shows minimal impact. While one study found no significant effect on IL-6 and TNF-α, hs-CRP levels could decrease or remain unchanged. Further meta-analyses are needed to fully understand Sumac's potential benefits in managing metabolic diseases.

Sobre autores

Hossein Bahari

Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Sheida Zeraattalab-Motlagh

Department of Health & Human Performance, University of Houston

Email: info@benthamscience.net

Zohreh Sajadi Hezaveh

Department of Health Sciences, Faculty of Medicine and Health, The University of Sydney

Email: info@benthamscience.net

Zahra Namkhah

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Haniyeh Golafrouz

Department of Medical Sciences and Technologies, Science & Research Branch, Islamic Azad University Central Tehran Branch

Email: info@benthamscience.net

Shaghayegh Taheri

Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences

Email: info@benthamscience.net

Amirhossein Sahebkar

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University

Autor responsável pela correspondência
Email: info@benthamscience.net

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