Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents

Vikas Kumar; Akshay Kumar; Vommina Sureshbabu; Swapandeep Chimni

doi:10.2174/18715206113136660368

Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents

Authors: Kumar V.¹, Kumar A.², Sureshbabu V.³, Chimni S.⁴
Affiliations:
1. aff1
2. aff2
3. aff3
4. aff4
Issue: Vol 14, No 6 (2014)
Pages: 910-920
Section: Oncology
URL: https://kld-journal.fedlab.ru/1871-5206/article/view/695109
DOI: https://doi.org/10.2174/18715206113136660368
ID: 695109

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Abstract

Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d (NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than 5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino acid residues on the tumor growth inhibitory activity has also been studied.