INTERACTION OF MRNA WITH THE C-TERMINAL DOMAIN OF PCID2, A SUBUNIT OF THE TREX-2 COMPLEX, IS REQUIRED FOR ITS EXPORT FROM THE NUCLEUS TO THE CYTOPLASM IN  DROSOPHILA MELANOGASTER

Y. A. Vdovina; Вдовина Ю. А.; S. G. Georgieva; Георгиева С. Г.; D. V. Kopytova; Копытова Д. В.

doi:10.31857/S268673892360053X

INTERACTION OF MRNA WITH THE C-TERMINAL DOMAIN OF PCID2, A SUBUNIT OF THE TREX-2 COMPLEX, IS REQUIRED FOR ITS EXPORT FROM THE NUCLEUS TO THE CYTOPLASM IN DROSOPHILA MELANOGASTER

作者: Vdovina Y.A.¹, Georgieva S.G.¹, Kopytova D.V.¹
隶属关系:
1. Institute of Molecular Biology, Russian Academy of Sciences
期: 卷 513, 编号 1 (2023)
页面: 586-589
栏目: Articles
URL: https://kld-journal.fedlab.ru/2686-7389/article/view/651060
DOI: https://doi.org/10.31857/S268673892360053X
EDN: https://elibrary.ru/GPVOWL
ID: 651060

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详细

Following the transcription step, the newly synthesized mRNA is exported from the nucleus to the cytoplasm and further to the translation site. The TREX-2 complex is involved in the step of mRNA export from the nucleus to the cytoplasm. This complex in Drosophila melanogaster consists of four proteins: Xmas-2, PCID2, ENY2, Sem1p. In our work, we have shown that deletion of the C-terminal sequence of PCID2 leads to a decrease in the interaction of the protein with RNA and to impaired mRNA export from the nucleus to the cytoplasm in D. melanogaster.

关键词

TREX-2, PCID2, mRNA export, transcription

参考

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