Determination of the elemental homeostasis in children population in Zabaikalsky Krai by multi-element instrumental neutron activation analysis

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Abstract

Introduction. The biogeochemical environment of the territory of the Eastern Zabaikalye is characterized by excess, deficiency or unfavourable ratio of many macro- and microelements in soil, water and vegetation. This is due to the metallogenic characteristics of the region and industrial mining activities, carried out for more than three hundred years.

The aim of the study was to investigate the accumulation of chemical elements in the hair in children and to identify specifics in their distribution depending on the naturally occurring and technogenic factors.

Materials and method. Hair samples were taken from seventy nine 5-12 years children living in the areas of geochemical anomalies and in the administrative centre of the region, Chita. The elemental composition of the samples for 28 chemical elements was determined by multi-element instrumental neutron activation analysis (INAA). Statistical processing of the results was carried out using nonparametric methods, concentration coefficients were calculated relative to the regional background.

Results. In settlements (V-Shakhtaminsky, Sherlovaya Gora, Kalga, Urulyungui) located in the zone of geochemical anomalies, which formation is associated with the presence of various and numerous deposits of lead-zinc, gold-polymetallic, tin, molybdenum ore and mining operations, the maximum amount of substances with content exceeding the regional background is observed in the biosubstrate. The values of concentration ratios above the background were established for antimony, gold, arsenic, europium, ytterbium, silver, rare-earth elements, cobalt, chromium, zinc and iron.

Limitations. In studying the elemental homeostasis of children and adolescents living in natural and anthropogenic geochemical anomalies of Zabaikalsky Krai, the content of 28 chemical elements in hair was analyzed.

Conclusion. The revealed characteristics of distribution and accumulation of certain spectrum of chemical substances in biosubstrate in children and adolescents reflect both metallogenic features of each territory and technogenic impact, which allows forming an idea of a unique regional component of the elemental homeostasis in the population.

Compliance with ethical standards. The study was approved by the local ethical committee of Chita State Academy of Medicine, minutes of meeting No. 95 of 25.06.2019. Ethical principles of research were consistent with the principles of the Helsinki Declaration of 1975 and its revision in 1983.

Patient consent. Each participant of the study (or his/her legal representative) gave informed voluntary written consent to participate in the study and publish personal medical information in an impersonal form in the journal "Gigiena i Sanitariya (Hygiene and Sanitation, Russian journal)".

Contribution:
Mikhailova L.A., Bondarevich E.A. — the concept and design of the study, writing a text;
Baranovskaya N.V., Vitkovsky Yu.A. — writing a text, editing;
Zhornyak L.V. — biogeochemical data processing;
Epova E.S., Eremin O.V., Nimaeva B.V. — collection and processing of material;
Ageeva E.V. — sample preparation of biomaterial for analytical detections.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgment. The study was supported by the grant of Russian Science Foundation (Grant No. 20-64-47021 “Influence of lithological and geochemical specificity of mountainous landscapes of Siberia and the Far East on the formation of the elemental composition of the organism of mammals”) in the analysis of the material. 

Received: May 31, 2022 / Accepted: December 8, 2022 / Published: March 25, 2023

About the authors

Larisa A. Mikhailova

Chita State Medical Academy

Author for correspondence.
Email: mihailova-la@mail.ru
ORCID iD: 0000-0001-7470-990X

MD, PhD, Head of the Department of Hygiene of the Chita State Medical Academy of the Ministry of Health of the Russian Federation, Chita, 672000, Russian Federation.

e-mail: mihailova-la@mail.ru

Russian Federation

Natalia V. Baranovskaya

National Research Tomsk Polytechnic University

Email: noemail@neicon.ru
ORCID iD: 0000-0003-3729-800X
Russian Federation

Evgeny A. Bondarevich

Chita State Medical Academy

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0032-3155
Russian Federation

Yuri A. Vitkovsky

Chita State Medical Academy

Email: noemail@neicon.ru
ORCID iD: 0000-0001-9244-1038
Russian Federation

Lina V. Zhornyak

National Research Tomsk Polytechnic University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4170-1976
Russian Federation

Ekaterina S. Epova

Institute of Natural Resources, Ecology and Cryology Siberian branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
ORCID iD: 0000-0002-5670-6809
Russian Federation

Oleg V. Eremin

Institute of Natural Resources, Ecology and Cryology Siberian branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0849-4557
Russian Federation

Balzhit V. Nimaeva

Chita State Medical Academy

Email: noemail@neicon.ru
ORCID iD: 0000-0002-8029-6213
Russian Federation

Elena V. Ageeva

National Research Tomsk Polytechnic University

Email: noemail@neicon.ru
ORCID iD: 0000-0001-9104-9325
Russian Federation

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