Score exposition of chemical loads and their association with occupational risks in the modern manufacture of polyvinyl chloride
- Authors: Meshchakova N.M.1, Shayakhmetov S.F.1, Lemeshevskaya E.P.2, Zhurba O.M.1
-
Affiliations:
- East-Siberian Institute of Medical and Ecological Research
- Irkutsk State Medical University
- Issue: Vol 98, No 10 (2019)
- Pages: 1074-1078
- Section: OCCUPATIONAL HEALTH
- Published: 15.10.2019
- URL: https://kld-journal.fedlab.ru/0016-9900/article/view/639732
- DOI: https://doi.org/10.47470/0016-9900-2019-98-10-1074-1078
- ID: 639732
Cite item
Full Text
Abstract
Introduction. In the modern production of polyvinyl chloride (PVC), despite relatively low levels of air pollution of the working zone of the harmful substances, the problem of the negative effects of chemical factors on organism remains topical In this regard, the objective of the present study was the quantitative estimation of exposure of chemical loads (ECL) priority toxicants in PVC production and the identification of associated links with health indices.
Material and methods. In the work of the applied methods of hygienic studies using a methodology for assessing occupational risks of the method of calculation of exposure to the chemical load. To justify a connection with the profession of morbidity used method of correlation analysis.
Results. In PVC production average settlement values of ECL priority substances (vinyl chloride and 1.2 dichloroethane) for the 10-year period were was shown to gradually decrease and be statistically significantly higher: during the first five-year period in comparison with the second, at mechanics in comparison with bureaucrats, in the shop of production of PVC in comparison with the shop of production of VH (р <0.01; р <0.001). When studying the health state of workers, the high prevalence of occupational risks was also noted rather functional violations of a cardiovascular system (31.2±5.1), neurologic frustration (28.0±3.2), functional violations of a digestion system (26.3±3.4). At medical examination diseases of a cardiovascular system (43.4±5.9), the nervous system (29.5±4.9), the system of digestion had the greatest prevalence (19.7±4.0). Correlation relationships between separate indices of the violation of health and quantitative indices of ECL are revealed.
Conclusion. For example, in employees of a modern PVC production, the results demonstrate it to be possible to identify an association between health and ECL, reflecting the cumulative impact of chemical pollutants production media after years of work at the enterprise. There was confirmed the usefulness of calculations specified ECL for linking disease with an occupation, particularly in the context of the effects of low concentrations of chemicals.
About the authors
Nina M. Meshchakova
East-Siberian Institute of Medical and Ecological Research
Author for correspondence.
Email: nina.meschakova@yandex.ru
ORCID iD: 0000-0002-9772-0199
MD, Ph.D., DSci., Associate Professor, researcher of the of ecological and hygienic researches, East-Siberian Institute of Medical and Ecological Research, Angarsk, 665827, Russian Federation.
e-mail: nina.meschakova@yandex.ru
Russian FederationS. F. Shayakhmetov
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0001-8740-3133
Russian Federation
E. P. Lemeshevskaya
Irkutsk State Medical University
Email: nina.meschakova@yandex.ru
ORCID iD: 0000-0002-7864-5998
Russian Federation
O. M. Zhurba
East-Siberian Institute of Medical and Ecological Research
Email: noemail@neicon.ru
ORCID iD: 0000-0002-9961-6408
Russian Federation
References
- Results and prospects for the production of PVC. Available at:https://packbel.by/mag/analitika/kakie-perspektivy-u-proizvoditelej-pvh (accessed 17 June 2019). (in Russian)
- Antonjuzhenko V.A. Hydrocarbon nejrotoksikoz [Uglevodorodnyy neyrotoksikoz]. Gorky: Volgo-Vyatskoe knizhnoe izdatel’stvo; 1980. 183 p. (in Russian)
- Savchenkov M.F., Lemeshevskaya E.P., Katul’skij Y.N., Benemanskij V.V., Zhukova E.V., Pogorelova I.G. et al. Combined effects caused by chronic exposure to vinyl chloride and dichloroethane. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2001; 1: 23–6. (in Russian)
- Bodyenkova G.М. Peculiarities of immunologic reactivity neurotoxic in workers exposed to various chemicals. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2008; 8: 1–6. (in Russian)
- Kudaeva I.V., Demidova M.P., Budarina L.A., Masnavieva L.B. Тhе state of gastro-intestial tract organs in persons exsposed to chlorinated hydrocarbons. Ekologiya cheloveka [Human Ecology]. 2009; 3: 9–12. (in Russian)
- Kudayeva I.V., Masnavieva L.B. Index state of neuromediator metabolism in rats after chronic intoxication with vinil chloride. Byulleten’ VSNTs SO RAMN. 2009; 1: 244–7. (in Russian)
- Sherman M. Vinyl chloride and the liver. J Hepatol. 2009; 51 (6): 1074–81. https://doi.org/10.1016/j.jhep.2009.09.012
- Mogilenkova L.A. Evaluating health state of chemical industry workers. [Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2010; 3: 43–8. (in Russian)
- Wang X.X., Xiao J.W., Meng H.L., Cui T., Niu K.L., Li B. Effect of vinyl chloride on reproductive and endocrine system of male rats. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010; 28 (7): 517–20.
- Ji F., Wang W., Xia Z.L., Zheng Y.J., Qiu Y.L., Wu F. et al. Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. Carcinogenesis. 2010; 31 (4); 648–53. https://doi.org/10.1093/carcin/bgq015
- Alexeyev R.Yu. Regular variation of immunoreactive workers in contact chlorinated hydrocarbons. Byulleten’ VSNTs SO RAMN. 2011; 79 (3–1): 143–7. (in Russian)
- Brandt-Rauf P.W., Li Y., Long C., Monaco R., Kovvali G., Marion M.J. Plastics and carcinogenesis: The example of vinyl chloride. J Carcinog. 2012; 11: 50–60. https://doi.org/10.4103/1477-3163.93700
- Taranenko N.A., Meshchakova N.M., Zhurba O.M., Telezhkin V.V. On the problem of the study of the chemical air pollution with chlororganic hydrocarbons at productions of polyvinyl chloride and epichlorohydrin. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2014; 4: 47–51. (in Russian)
- Meshchakova N.M., Sosedova L.M., Shayakhmetov S.F., Lemeshevskaya E.P., Kapustina E.A., Dyakovich M.P. et al. Toxic-hygienic aspects of the influence of working conditions on the health of workers in the production of vinyl chloride and polyvinyl chloride: monograph. [Toksiko-gigienicheskie aspekty vliyaniya usloviy truda na zdorov’e rabotayushchikh v proizvodstve vinilkhlorida i polivinilkhlorida: monografiya]. Irkutsk: NTsRVKhSO RAMN; 2014. 166 p. (in Russian)
- Katamanova E.V., Dyakovich M.P., Kudaeva I.V., Shevchenko O.I., Eshchina I.M., Rukavishnikov V.S. et al. Clinical and neurophysiological peculiarities of health disorders in workers in dependence on the vinyl chloride exposure load. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 12: 1167–71. https://doi.org/10.18821/0016-9900-2016-95-12-1167-1171 (in Russian)
- Katamanova E.V., Eshchina I.M., Kudaeva I.V., Masnavieva L.B., Dyakovich M.P. Change of some biochemical indices depending on exposure load in staff workers in contact with vinyl chloride. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97 (10): 910–14. https://doi.org/10.18821/0016-9900-2018-97-10-910-914 (in Russian)
- Fazeul H. Molecular modeling analysis of the metabolism of vinyl chloride. J Pharmacol Toxicol. 2006; 4 (1): 299–316.
- The Environmental health criteria 215. Vinyl Chloride. Geneva: International Programme on Chemical Safety; 1999.
- Zhurba O.M. Assessment of the metabolite of chlororganic pollutants content in urine of workers of polyvinychloride production. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2019; 98 (1): 55–60. https://doi.org/10.18821/0016-9900-2019-98-1-55-60 (in Russian)
- Mundt K.A., Dell L.D., Austin R.P., Luippold R.S., Noess R., Bigelow C. Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942-72: update of cancer mortality to 31 December 1995. Occup Environ Med. 2000; 57 (11): 774–81. https://doi.org/10.1136/oem.57.11.774
- Ward E., Boffetta P., Andersen A., Colin D., Comba P., Deddens J.A. et al. Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry. Epidemiology. 2001; 12 (6): 710–8.
- Zhu S.M., Ren X.F., Wan J.X., Xia Z.L. Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes. World J Gastroenterol. 2005; 11 (37): 5821–7. https://doi.org/10.3748/wjg.v11.i37.5821
- Kudayeva I.V., Boudarina L.A., Masnaviyeva L.B. Patterns of biochemical disorders under exposure to neurotoxic chemicals varying in nature. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2008; 8: 7–11. (in Russian)
- Merkulov V.I. Dichloroethane. Toxic properties and poisoning. Toksikologicheskiy vestnik. 2001; 6: 19–22. (in Russian)
- Fomin M.V., Alikbayeva L.A., Lukovnikova L.V., Sidorin G.I., Petrova N.N. Hygienic substantiation of the safety operation of the enterprise for the production of polyvinyl chloride. Gigiyena i sanitariya [Hygiene and Sanitation, Russian journal]. 2017; 96 (4): 347–51. https://doi.org/10.18821/0016-9900-2017-96-4-347-351 (in Russian)
- Timofeeva S.S., Bodienkova G.M. Cancerogenic risks of vinyl chloride production. Tekhnosfernaya bezopasnost’. 2017; 2 (2): 57–67. (in Russian)
- Meshchakova N.M., Lemeshevskaya E.P., Shayakhmetov S.F., Zhurba O.M. Hygienic monitoring of the main unfavorable factors in the production of vinylchloride and polyvinylchloride in Eastern Siberia. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2017; 10: 42–7. (in Russian)
- Meshchakova N.M., Dyakovich M.Р., Shayakhmetov S.F. Assessment of occupational take for the workers of chemical productions taking into account the display toxic loading. Methodical recommendations [Otsenka professional’nogo riska u rabotnikov khimicheskikh proizvodstv s uchotom ekspozitsionnoy toksicheskoy nagruzki: metodicheskiye rekomendatsii]. Irkutsk: 2013. (in Russian)
- Zakharenkov V.V., Oleschenko A.M., Danilov I.P. Automated information system for assessing occupational risks for the health of industrial workers: medical technology [Avtomatizirovannaya informatsionnaya sistema otsenki professional’nogo riska dlya zdorov’ya rabotnikov promyshlennykh predpriyatiy: meditsinskaya tekhnologiya]. Novokuznetsk; 2013. (in Russian)
- Bukhtiyarov I.V., Denisov E.I., Lagutina G.N., Pfaf V.F., Chesalin P.V., Stepanyan I.V. Сriteria and algorithms of workrelatedness assessment of workers health disorders. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2018; 8: 4–12. https://doi.org/10.31089/1026-94282018-8-4-12 (in Russian)
- Fedoruk A.A., Rosly O.F. Fluoric loading as marker of development of a professional flyuoroz. Meditsina truda i promyshlennaya ekologiya [Russian Journal of Occupational Health and Industrial Ecology]. 2015; 9: 146. (in Russian)
- Zakharenkov V.V., Koljado V.B., Burdejn V.A., Oleshchenko A.M., Viblaja I.V., Panev N.I. et al. Health and the preservation of employment capacity of the population of large industrial region: monograph [Zdorov’ye i sokhraneniye trudovogo potentsiala naseleniya krupnogo promyshlennogo regiona: monografiya]. Novokuznetsk; 2011: 100–7. (in Russian)
Supplementary files
