Analysis of cardiac troponins to determine the drugs cardiotoxicity
- Authors: Sheshurina T.A.1,2, Dorofeykov V.V.1,3
-
Affiliations:
- The Lesgaft National State University of Physical Education, Sports and Health
- City medical and physical education dispensary
- Almazov National Medical Research Centre
- Issue: Vol 69, No 1 (2024)
- Pages: 5-18
- Section: Reviews
- Published: 18.12.2024
- URL: https://kld-journal.fedlab.ru/0869-2084/article/view/636975
- DOI: https://doi.org/10.17816/cld636975
- ID: 636975
Cite item
Abstract
In modern medicine, the problem of the toxic effect of drugs on the human body persists. Cardiotoxicity is damage to the heart muscle by drugs and biologically active additives is one of the most common negative consequences. The task of doctors is to identify the presence of cardiotoxicity in the early stages before the appearance of clinical symptoms, timely adjust therapy and add cardioprotectors if necessary. Today, the main methods of diagnosing cardiotoxicity are imaging methods — echocardiography and magnetic resonance imaging. These methods show structural changes in the myocardium that have already occurred and a decrease in the working indicators of the heart. The active implementation and development of an algorithm for the use of troponin tests before and during therapy by drugs with cardiotoxic effects makes it possible to identify high-risk patients, diagnose damage to the heart muscle earlier and reduce the number of studies. The review analyzes trials in which cardiac troponins were used as cardiotoxicity markers of various drugs, shows the technical limitations of laboratory methods for troponin T and I tests, and the prospects for predictive use of determining highly sensitive tests for cardiac troponins.
Keywords
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About the authors
Tatyana A. Sheshurina
The Lesgaft National State University of Physical Education, Sports and Health; City medical and physical education dispensary
Author for correspondence.
Email: mitralis@list.ru
ORCID iD: 0000-0003-1221-2396
SPIN-code: 3315-4018
MD, Cand. Sci. (Medicine)
Russian Federation, St. Petersburg; St. PetersburgVladimir V. Dorofeykov
The Lesgaft National State University of Physical Education, Sports and Health; Almazov National Medical Research Centre
Email: vdorofeykov@ya.ru
ORCID iD: 0000-0002-7272-1654
SPIN-code: 6462-6448
MD, Dr. Sci. (Medicine)
Russian Federation, St. Petersburg; St. PetersburgReferences
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