Direct method for determining the reference values of thyroid function for Mindray analyzers
- 作者: Roytman A.P.1, Bugrov A.V.1, Rakova N.G.1, Shustov V.V.2, Dolgov V.V.1, Godkov M.A.1,2
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隶属关系:
- Russian Medical Academy of Continuous Professional Education
- Sklifosovsky Research Institute For Emergency Medicine
- 期: 卷 69, 编号 6 (2024)
- 页面: 44-51
- 栏目: Original Study Articles
- ##submission.datePublished##: 25.05.2024
- URL: https://kld-journal.fedlab.ru/0869-2084/article/view/629845
- DOI: https://doi.org/10.17816/cld629845
- ID: 629845
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BACKGROUND: In addition to important individual consequences in patients, errors in the interpretation of the study results in terms of the boundaries in the reference intervals of laboratory markers of thyroid function can lead to hypo- or overdiagnosis and the associated use of drugs, that can have negative effects on the healthcare system. Therefore, the assessment of the relevant reference intervals is crucial in laboratory medicine.
AIM: To determine the reference intervals of thyroid hormones in blood samples of an adult (aged 18–78 years) population of the European part of the Russian Federation using reagent kits for quantitative total and free thyroxine, total and free triiodothyronine, thyroglobulin, and thyroid-stimulating hormones in human clinical samples by immunochemiluminescent method using Mindray analyzers of the CL series (Shenzhen Mindray Bio-Medical Electronics Co., China).
MATERIALS AND METHODS: The study included 269 patients aged 18–78 years. The quantitative determination of the parameters of thyroid function in serum samples was performed on the Mindray Cl 6000i automatic analyzer.
RESULTS: Reliable reference intervals characterizing thyroid function were obtained for thyroid-stimulating hormone (0,64–4,36 µIU/mL), free (2,39–3,79 pg/mL) and total (0,66–1,28 ng/mL) triiodothyronine, free (0,62–1,13 ng/dL) and total (5,04–0,54 µg/dL) thyroxine and thyroglobulin (2,04–48,2 ng/mL) in blood samples of the adult population (aged 18–78 years) of the European part of the Russian Federation.
CONCLUSION: Established reference intervals for diagnostic purposes on the basis of appropriate clinical recommendations must be used. A personalized approach is necessary to interpret the obtained laboratory research data and compare it with anamnesis, data from imaging research methods and clinical patterns.
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作者简介
Alexandr Roytman
Russian Medical Academy of Continuous Professional Education
编辑信件的主要联系方式.
Email: a-roitman@mail.ru
ORCID iD: 0000-0003-2592-6857
SPIN 代码: 5400-7815
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, MoscowAleksey Bugrov
Russian Medical Academy of Continuous Professional Education
Email: avb81@bk.ru
ORCID iD: 0000-0003-1404-4699
SPIN 代码: 4321-6433
MD, Cand. Sci. (Medicine), Assistant Professor
俄罗斯联邦, MoscowNatalia Rakova
Russian Medical Academy of Continuous Professional Education
Email: n_rakova@mail.ru
ORCID iD: 0000-0002-1168-6795
SPIN 代码: 2133-9848
MD, Cand. Sci. (Medicine), Assistant Professor
俄罗斯联邦, MoscowValeriy Shustov
Sklifosovsky Research Institute For Emergency Medicine
Email: shustov_valeriy@mail.ru
ORCID iD: 0000-0002-9624-5883
SPIN 代码: 7474-5516
MD
俄罗斯联邦, MoscowVladimir Dolgov
Russian Medical Academy of Continuous Professional Education
Email: vvdolgov@inbox.ru
ORCID iD: 0000-0003-1537-7444
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, MoscowMikhail Godkov
Russian Medical Academy of Continuous Professional Education; Sklifosovsky Research Institute For Emergency Medicine
Email: mgodkov@yandex.ru
ORCID iD: 0000-0002-0854-8076
SPIN 代码: 4871-6150
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Moscow; Moscow参考
- Troshina EA, Platonova NM, Panfilova EA. Dynamics of epidemiological indicators of thyroid pathology in the population of the Russian Federation: analytical report for the period 2009–2018. Problems of Endocrinology. 2021;67(2):10–19. doi: 10.14341/probl12433
- Natalya Mokrysheva, Director of the National Medical Center of Endocrinology of the Ministry of Health of the Russian Federation, on measures to prevent thyroid diseases [Internet]. Ministry of Health of the Russian Federation. Available from: https://minzdrav.gov.ru/news/2022/05/25/18761 (In Russ)
- Selivanova AV, Dolgov VV. Interpretation of laboratory tests in thyroid pathology. Moscow: GEOTAR-Media; 2023. (In Russ). EDN: OZYMZD
- Clinical and Laboratory Standards Institute (CLSI). EP28-A3c Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline—Third Edition. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
- Sencha AN. Ultrasound examination of the thyroid gland. From simple to complex. Moscow: MEDpress-inform; 2023. (In Russ). EDN: WIGVYA
- Bataeva RS, Mitkov VV, Mitkova MD. Reproducibility of a Thyroid Gland Ultrasound Volumetry. Ultrasound and functional diagnostics. 2006;(1):37–42. EDN: JXBHNB
- Mitkov VV, editor. A practical guide to ultrasonography. General ultrasound diagnostics. Moscow: Vidar-M; 2019. (In Russ).
- Evgina SA, Saveliev LI. Current theory and practice of reference interval. Laboratory Service. 2019;8(2):36–44. EDN: LXSKCN doi: 10.17116/labs2019802136