Antibiotic resistance of obligate anaerobes isolated from patients with coloproctological diseases

Alina R. Melkumyan; Мелкумян Алина Рантиковна; Sergey I. Achkasov; Ачкасов Сергей Иванович; Anastasia A. Shafikova; Шафикова Анастасия Александровна; Daria A. Chistyakova; Чистякова Дарья Алексеевна; Mikhail V. Spivak; Спивак Михаил Владимирович; Olga E. Orlova; Орлова Ольга Евгеньевна; Svetlana A. Gordeeva; Гордеева Светлана Александровна; Zhanna V. Khamtsova; Хамцова Жанна Валерьевна; Antonina V. Vetokhina; Ветохина Антонина Владиславовна

doi:10.17816/cld640813

Antibiotic resistance of obligate anaerobes isolated from patients with coloproctological diseases

Авторлар: Melkumyan A.R.¹^,2, Achkasov S.I.¹^,2, Shafikova A.A.¹, Chistyakova D.A.¹, Spivak M.V.¹, Orlova O.E.³, Gordeeva S.A.⁴, Khamtsova Z.V.⁵, Vetokhina A.V.⁶
Мекемелер:
1. State Scientific Centre of Coloproctology named after A.N. Ryzhih
2. Russian Medical Academy of Continuous Professional Education
3. City Clinical Hospital No. 67 named after L.A. Vorohobov
4. Clinical Infectious Diseases Hospital named after S.P. Botkin
5. Center for Specialized Types of Medical Care named after. V.P. Avaev
6. Irkutsk Order of the Badge of Honor Regional Clinical Hospital
Шығарылым: Том 69, № 9 (2024)
Беттер: 175-185
Бөлім: Original Study Articles
##submission.datePublished##: 18.02.2024
URL: https://kld-journal.fedlab.ru/0869-2084/article/view/640813
DOI: https://doi.org/10.17816/cld640813
ID: 640813

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Аннотация
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Әдебиет тізімі
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Статистика

Аннотация

BACKGROUND: Anaerobic infections are life-threatening, often severe, and dangerous for patients with comorbidities. However, in the routine practice of microbiological laboratories, anaerobes are usually not cultured or identified, and the susceptibility of obligate anaerobes to antibiotics is rarely determined. However, antibiotic resistance has increased worldwide, including among anaerobic bacteria.

AIM: The aim of the study was to evaluate the susceptibility of etiologically significant species of obligate anaerobic bacteria isolated from patients with coloproctological diseases from different regions of the Russian Federation.

MATERIALS AND METHODS: The multicenter, prospective, uncontrolled study included etiologically significant obligate anaerobes isolated from patients with coloproctological diseases in 65 regions of the Russian Federation. Subsequent evaluation of antibiotic susceptibility was performed in accordance with the regulatory documents used in the Russian Federation.

RESULTS: As a result of the study, 1,200 strains of obligate anaerobes of 123 species were collected. The analysis included the results of susceptibility testing of 430 anaerobic strains causing proctological infections, including Bacteroides (n =202), Parabacteroides (n =22), Phocaeicola vulgatus (n =104), Prevotella (n =11), Clostridium perfringens (n =91). Resistance to metronidazole, clindamycin, meropenem and vancomycin was detected in 77.3%, 72.7%, 62.5% and 8.79% of the strains, respectively.

CONCLUSION: Monitoring for antibiotic resistance in obligate anaerobes that pose a threat of spreading antibiotic-resistant strains helps reduce the spread of resistance and personalizes antimicrobial therapy and prevention protocols for patients, reducing treatment costs and hospital stay time by quickly switching from empiric to etiotropic therapy.

Негізгі сөздер

anaerobic bacteria, antibacterial agents, drug resistance of microorganisms, bacterial drug resistance, surgical wound infection, postoperative wound infection, postoperative complications

Толық мәтін

Авторлар туралы

Alina Melkumyan

State Scientific Centre of Coloproctology named after A.N. Ryzhih; Russian Medical Academy of Continuous Professional Education

Хат алмасуға жауапты Автор.
Email: alinamelkumyan@yandex.ru
ORCID iD: 0000-0002-5494-415X
SPIN-код: 2313-8930

MD, Cand. Sci. (Medicine)

Ресей, 2 Salyama Adilya street, 123423 Moscow; Moscow

Sergey Achkasov

State Scientific Centre of Coloproctology named after A.N. Ryzhih; Russian Medical Academy of Continuous Professional Education

Email: info@gnck.ru
ORCID iD: 0000-0001-9294-5447
SPIN-код: 5467-1062

MD, Dr. Sci. (Medicine), Professor, corresponding member of the Russian Academy of Sciences

Ресей, 2 Salyama Adilya street, 123423 Moscow; Moscow

Cand. Sci. (Biology)

Ресей, Moscow

Әдебиет тізімі

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Қосымша файлдар

Әрекет

1. JATS XML

Жүктеу

2. Fig. 1. Distribution of patients by place of residence.

Жүктеу (381KB)

Метадеректер

3. Fig. 2. The number of patients, in accordance with the diagnoses according to ICD-10, from whom strains of the collection of obligate anaerobic microorganisms were obtained.